Tbio RNASET2 Ribonuclease T2

Protein Summary

Description

Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00584
• B2RDA7
• E1P5C3
• Q5T8Q0
• Q8TCU2
• Q9BZ46
• Q9BZ47

Gene Name

• RNASET2

Ensembl ID

• ENST00000421787
• ENSP00000390833
• ENSG00000026297
• ENST00000476238
• ENSP00000422846
• ENST00000508775
• ENSP00000426455

Symbol

• RNASE6PL
• RNASE6PL
• bA514O12.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
virus perturbation	0.88
kinase perturbation	0.81
histone modification site profile	0.71
cellular component	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0