Tbio SERINC5 Serine incorporator 5

Protein Summary

Description

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

Uniprot Accession IDs

• Q86VE9
• B4DMH7
• Q495A4
• Q495A6

Gene Name

• SERINC5

Ensembl ID

• ENST00000507668
• ENSP00000426237
• ENSG00000164300
• ENST00000509193
• ENSP00000426134
• ENST00000512972
• ENSP00000421665

Symbol

• C5orf12
• TPO1
• C5orf12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
transcription factor binding site profile	0.84
microRNA	0.73
histone modification site profile	0.72
cell type or tissue	0.71

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Serine Incorporator 5

DTO Classes

Protein / Receptor / Serine Incorporator 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.79   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.79   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0