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Tbio
TMEM33
Transmembrane protein 33

Protein Summary
Description
Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325094
  • ENSP00000441455
  • ENSG00000109133
  • ENST00000504986
  • ENSP00000422473
  • ENST00000513702
  • ENSP00000427006

Symbol
  • DB83
  • Pom33
  • SHINC3
  • SHINC-3
  • 1600019D15Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.92
microRNA
0.92
virus perturbation
0.88
transcription factor binding site profile
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0