Tbio PDGFC Platelet-derived growth factor C

Protein Summary

Description

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9NRA1
• B4DU34
• B9EGR8
• Q4W5M9
• Q9UL22
• PDGF-C

Gene Name

• PDGFC

Ensembl ID

• ENST00000422544
• ENSP00000410048
• ENSG00000145431
• ENST00000502773
• ENSP00000422464

Symbol

• SCDGF
• SCDGF
• FALLOTEIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
transcription factor perturbation	0.96
gene perturbation	0.82
biological process	0.75
transcription factor binding site profile	0.73

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Platelet-derived Growth Factor C

DTO Classes

Protein / Signaling / Growth Factor / Platelet-derived Growth Factor C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.7   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.7   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0