Tchem ADH7 Alcohol dehydrogenase class 4 mu/sigma chain

Protein Summary

Description

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P40394
• A2RRB6
• A8MVN9
• B2R760
• B4DWV6
• Q13713

Gene Name

• ADH7

Ensembl ID

• ENST00000209665
• ENSP00000209665
• ENSG00000196344
• ENST00000476959
• ENSP00000420269

Symbol

• ADH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
protein domain	0.92
disease perturbation	0.79
pathway	0.75
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Alcohol Dehydrogenase Class 4 Mu/sigma Chain

Protein / Oxidoreductase / Dehydrogenase / Alcohol Dehydrogenase Class 4 Mu/sigma Chain

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Alcohol Dehydrogenase Class 4 Mu/sigma Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.5   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.5   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0