Tbio MICAL3 [F-actin]-monooxygenase MICAL3

Protein Summary

Description

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.

Uniprot Accession IDs

• Q7RTP6
• B2RXJ5
• E9PEF0
• O94909
• Q5U4P4
• Q6ICK4
• Q96DF2
• Q9P2I3

Gene Name

• MICAL3

Ensembl ID

• ENST00000383094
• ENSP00000372574
• ENSG00000243156
• ENST00000400561
• ENSP00000383406
• ENST00000414725
• ENSP00000391827
• ENST00000441493
• ENSP00000416015
• ENST00000585038
• ENSP00000462033

Symbol

• KIAA0819
• KIAA1364
• MICAL-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
microRNA	0.98
molecular function	0.93
protein domain	0.85
histone modification site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.83   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.83   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0