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Tbio
C4B
Complement C4-B

Protein Summary
Description
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375177
  • ENSP00000364321
  • ENSG00000228454
  • ENST00000411583
  • ENSP00000407942
  • ENSG00000228267
  • ENST00000435363
  • ENSP00000415941
  • ENSG00000224389
  • ENST00000435500
  • ENSP00000412786
  • ENSG00000233312
  • ENST00000449788
  • ENSP00000414200
  • ENSG00000236625

Symbol
  • CO4
  • CPAMD3
  • CH
  • C4F
  • CO4
  • C4B1
  • C4B2
  • C4B3
  • C4B5
  • C4BD
  • C4B12
  • C4B_2
  • CPAMD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
biological term
0.82
small molecule perturbation
0.81
cell line
0.68
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1957.9   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1957.9   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0