Tbio MAMLD1 Mastermind-like domain-containing protein 1

Protein Summary

Description

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q13495
• B2RCQ4
• B4DG93
• B9EGA5

Gene Name

• MAMLD1

Ensembl ID

• ENST00000262858
• ENSP00000262858
• ENSG00000013619
• ENST00000370401
• ENSP00000359428
• ENST00000426613
• ENSP00000397438
• ENST00000432680
• ENSP00000414517

Symbol

• CG1
• CXorf6
• CG1
• F18
• HYSP2
• CXorf6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.74
tissue sample	0.6
transcription factor	0.58
small molecule perturbation	0.52
biological process	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.6   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.6   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0