Tbio KRT3 Keratin, type II cytoskeletal 3

Protein Summary

Description

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12035
• A6NIS2
• Q701L8

Gene Name

• KRT3

Ensembl ID

• ENST00000417996
• ENSP00000413479
• ENSG00000186442

Symbol

• K3
• CK3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.82
cellular component	0.54
cell line	0.53
cell type or tissue	0.44
protein domain	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.45   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.45   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0