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Tbio
CSGALNACT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

Protein Summary
Description
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity). This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332246
  • ENSP00000330805
  • ENSG00000147408
  • ENST00000397998
  • ENSP00000381084
  • ENST00000454498
  • ENSP00000411816
  • ENST00000519222
  • ENSP00000428216
  • ENST00000522854
  • ENSP00000429809

Symbol
  • CHGN
  • GALNACT1
  • ChGn
  • ChGn-1
  • CSGalNAcT-1
  • beta4GalNAcT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
pathway
0.92
PubMedID
0.76
small molecule perturbation
0.7
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.11   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.11   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0