Protein Summary
Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during th ...more
- ENST00000236693
- ENSP00000236693
- ENSG00000118004
- ENST00000349077
- ENSP00000339168
- ENST00000382062
- ENSP00000371494
- ENST00000402794
- ENSP00000384882
- ENST00000402922
- ENSP00000385653
- ENST00000403096
- ENSP00000385130
- ENST00000404205
- ENSP00000385827
- ENST00000418971
- ENSP00000411770
- 3MC2
- CLK1
- CL-K1-I
- CL-K1-II
- CL-K1-IIa
- CL-K1-IIb
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.74 | ||
protein domain | 0.73 | ||
cell line | 0.63 | ||
tissue sample | 0.63 | ||
tissue | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.26 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.26 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0