ITPKB
Inositol-trisphosphate 3-kinase B
Protein Summary
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
- ENST00000272117
- ENSP00000272117
- ENSG00000143772
- ENST00000366784
- ENSP00000355748
- ENST00000429204
- ENSP00000411152
- IP3K
- IP3KB
- PIG37
- IP3K-B
- IP3-3KB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.93 | ||
molecular function | 0.93 | ||
PubMedID | 0.84 | ||
cell type or tissue | 0.79 | ||
cell line | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.06 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 201 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.06 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 201 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0