Tbio MOGAT1 2-acylglycerol O-acyltransferase 1

Protein Summary

Description

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity). Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q96PD6
• Q6IEE5

Gene Name

• MOGAT1

Ensembl ID

• ENST00000446656
• ENSP00000406674
• ENSG00000124003

Symbol

• DC2
• DGAT2L1
• MGAT1
• DGAT2L
• DGAT2L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
histone modification site profile	0.69
cell type or tissue	0.68
gene perturbation	0.6
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / 2-acylglycerol O-acyltransferase 1

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / 2-acylglycerol O-acyltransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.38   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.38   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0