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Tbio
TDRD5
Tudor domain-containing protein 5

Protein Summary
Description
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294848
  • ENSP00000294848
  • ENSG00000162782
  • ENST00000367614
  • ENSP00000356586
  • ENST00000444136
  • ENSP00000406052

Symbol
  • TUDOR3
  • TUDOR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
gene perturbation
0.65
cell line
0.61
cell type or tissue
0.56
interacting protein
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0