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Tclin
DDC
Aromatic-L-amino-acid decarboxylase

Protein Summary
Description
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357936
  • ENSP00000350616
  • ENSG00000132437
  • ENST00000380984
  • ENSP00000370371
  • ENST00000426377
  • ENSP00000395069
  • ENST00000431062
  • ENSP00000399184
  • ENST00000444124
  • ENSP00000403644
  • ENST00000615193
  • ENSP00000484104

Symbol
  • AADC
  • AADC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
transcription factor perturbation
0.88
protein domain
0.85
disease
0.81
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 868.85   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 868.85   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1