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Tbio
ARHGAP27
Rho GTPase-activating protein 27

Protein Summary
Description
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290470
  • ENSP00000290470
  • ENSG00000159314
  • ENST00000376922
  • ENSP00000366121
  • ENST00000428638
  • ENSP00000403323
  • ENST00000528273
  • ENSP00000436137
  • ENST00000610792
  • ENSP00000477741
  • ENSG00000276907
  • ENST00000611188
  • ENSP00000481302
  • ENST00000612916
  • ENSP00000480582
  • ENSG00000276836
  • ENST00000616021
  • ENSP00000478738
  • ENST00000633003
  • ENSP00000487991

Symbol
  • CAMGAP1
  • SH3D20
  • PP905
  • SH3D20
  • SH3P20
  • CAMGAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor
0.81
transcription factor binding site profile
0.72
tissue sample
0.66
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.35   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.35   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0