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Tbio
PERP
p53 apoptosis effector related to PMP-22

Protein Summary
Description
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421351
  • ENSP00000397157
  • ENSG00000112378

Symbol
  • KCP1
  • KRTCAP1
  • PIGPC1
  • THW
  • THW
  • KCP1
  • PIGPC1
  • KRTCAP1
  • dJ496H19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.91
virus perturbation
0.83
histone modification site profile
0.79
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.89   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.89   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0