Tbio ZNF746 Zinc finger protein 746

Protein Summary

Description

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Uniprot Accession IDs

• Q6NUN9
• A8K6Z9
• Q6ZRF9

Gene Name

• ZNF746

Ensembl ID

• ENST00000340622
• ENSP00000345140
• ENSG00000181220
• ENST00000458143
• ENSP00000395007

Symbol

• PARIS
• PARIS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
protein domain	0.73
cell type or tissue	0.69
biological process	0.64
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0