Tdark BTBD18 BTB/POZ domain-containing protein 18

Protein Summary

Description

Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.

Uniprot Accession IDs

• B2RXH4

Gene Name

• BTBD18

Ensembl ID

• ENST00000422652
• ENSP00000394472
• ENSG00000233436
• ENST00000436147
• ENSP00000397020

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.65
cellular component	0.64
tissue sample	0.57
virus perturbation	0.5
small molecule perturbation	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.51   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.51   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0