You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
FGFR1
Fibroblast growth factor receptor 1

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326324
  • ENSP00000327229
  • ENSG00000077782
  • ENST00000335922
  • ENSP00000337247
  • ENST00000356207
  • ENSP00000348537
  • ENST00000397091
  • ENSP00000380280
  • ENST00000397108
  • ENSP00000380297
  • ENST00000397113
  • ENSP00000380302
  • ENST00000425967
  • ENSP00000393312
  • ENST00000447712
  • ENSP00000400162
  • ENST00000484370
  • ENSP00000433163
  • ENST00000532791
  • ENSP00000432972

Symbol
  • BFGFR
  • CEK
  • FGFBR
  • FLG
  • FLT2
  • HBGFR
  • CEK
  • FLG
  • HH2
  • OGD
  • ECCL
  • FLT2
  • KAL2
  • BFGFR
  • CD331
  • FGFBR
  • FLT-2
  • HBGFR
  • N-SAM
  • FGFR-1
  • HRTFDS
  • bFGF-R-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
kinase
0.96
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1978.29   (req: < 5)
Gene RIFs: 534   (req: <= 3)
Antibodies: 2216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1978.29   (req: >= 5)
Gene RIFs: 534   (req: > 3)
Antibodies: 2216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1228
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11