Tbio KLLN Killin

Protein Summary

Description

DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA. The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• B2CW77

Gene Name

• KLLN

Ensembl ID

• ENST00000445946
• ENSP00000392204
• ENSG00000227268
• ENST00000635224
• ENSP00000489239
• ENSG00000283059
• ENST00000644082
• ENSP00000495113

Symbol

• CWS4
• KILLIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.73
tissue sample	0.62
transcription factor binding site profile	0.53
cell line	0.52
phenotype	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.9   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.9   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0