Tbio TMBIM6 Bax inhibitor 1

Protein Summary

Description

Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).

Uniprot Accession IDs

• P55061
• B2R5M4
• F8W034
• O14938
• Q643A7
• Q96J50
• BI-1

Gene Name

• TMBIM6

Ensembl ID

• ENST00000267115
• ENSP00000267115
• ENSG00000139644
• ENST00000395006
• ENSP00000378454
• ENST00000423828
• ENSP00000389277
• ENST00000549385
• ENSP00000448036
• ENST00000552370
• ENSP00000450158
• ENST00000552699
• ENSP00000446734

Symbol

• BI1
• TEGT
• BI-1
• TEGT
• BAXI1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
transcription factor binding site profile	0.93
co-expressed gene	0.87
disease perturbation	0.83
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1000.63   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1000.63   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0