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Tbio
TCF12
Transcription factor 12

Protein Summary
Description
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267811
  • ENSP00000267811
  • ENSG00000140262
  • ENST00000333725
  • ENSP00000331057
  • ENST00000343827
  • ENSP00000342459
  • ENST00000438423
  • ENSP00000388940
  • ENST00000537840
  • ENSP00000444696
  • ENST00000557843
  • ENSP00000453737

Symbol
  • BHLHB20
  • HEB
  • HTF4
  • HEB
  • p64
  • CRS3
  • HTF4
  • TCF-12
  • bHLHb20
  • HsT17266
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
transcription factor perturbation
0.98
kinase perturbation
0.96
molecular function
0.93
transcription factor
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.46   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.46   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0