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Tbio
NAA60
N-alpha-acetyltransferase 60

Protein Summary
Description
N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360862
  • ENSP00000354108
  • ENSG00000122390
  • ENST00000407558
  • ENSP00000385903
  • ENST00000414063
  • ENSP00000393224
  • ENST00000421765
  • ENSP00000405873
  • ENST00000424546
  • ENSP00000401237
  • ENST00000570819
  • ENSP00000460763
  • ENST00000572169
  • ENSP00000458928
  • ENST00000572584
  • ENSP00000459057
  • ENST00000572942
  • ENSP00000461730
  • ENST00000573580
  • ENSP00000459055
  • ENST00000575076
  • ENSP00000458667
  • ENST00000577013
  • ENSP00000458575
  • ENST00000649205
  • ENSP00000497988
  • ENST00000649360
  • ENSP00000497411

Symbol
  • HAT4
  • NAT15
  • HAT4
  • NatF
  • NAT15
  • hNaa60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.87
transcription factor
0.69
tissue sample
0.68
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0