Tbio ICA1 Islet cell autoantigen 1

Protein Summary

Description

May play a role in neurotransmitter secretion. This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• Q05084
• A8K7U1
• B3FTQ2
• P78506
• Q13824
• Q96HG3

Gene Name

• ICA1

Ensembl ID

• ENST00000265577
• ENSP00000265577
• ENSG00000003147
• ENST00000396675
• ENSP00000379908
• ENST00000402384
• ENSP00000385570
• ENST00000406470
• ENSP00000385651
• ENST00000422063
• ENSP00000403982

Symbol

• ICA69
• ICAp69

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor	0.77
transcription factor perturbation	0.74
virus perturbation	0.72
cellular component	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.57   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.57   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0