Tbio ZFPM2 Zinc finger protein ZFPM2

Protein Summary

Description

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WW38
• Q32MA6
• Q9NPL7
• Q9NPS4
• Q9UNI5

Gene Name

• ZFPM2

Ensembl ID

• ENST00000407775
• ENSP00000384179
• ENSG00000169946

Symbol

• FOG2
• ZNF89B
• DIH3
• FOG2
• SRXY9
• ZNF89B
• hFOG-2
• ZC2HC11B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
molecular function	0.91
biological process	0.88
PubMedID	0.84
phenotype	0.77

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein Zfpm2

Protein / Nucleic Acid Binding / Zinc Finger Protein Zfpm2

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein Zfpm2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.9   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.9   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0