Tclin CSF2RB Cytokine receptor common subunit beta

Protein Summary

Description

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P32927
• Q5JZI1
• Q6ICE0

Gene Name

• CSF2RB

Ensembl ID

• ENST00000403662
• ENSP00000384053
• ENSG00000100368
• ENST00000406230
• ENSP00000385271

Symbol

• IL3RB
• IL5RB
• CD131
• IL3RB
• IL5RB
• SMDP5
• CDw131
• betaGMR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.92
PubMedID	0.92
disease perturbation	0.83
protein domain	0.73
biological term	0.68

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Cytokine Receptor Common Subunit Beta

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Cytokine Receptor Common Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 656   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2