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Tbio
SIRPA
Tyrosine-protein phosphatase non-receptor type substrate 1

Protein Summary
Description
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356025
  • ENSP00000348307
  • ENSG00000198053
  • ENST00000358771
  • ENSP00000351621
  • ENST00000400068
  • ENSP00000382941
  • ENST00000622179
  • ENSP00000478763

Symbol
  • BIT
  • MFR
  • MYD1
  • PTPNS1
  • SHPS1
  • SIRP
  • BIT
  • MFR
  • P84
  • SIRP
  • MYD-1
  • SHPS1
  • CD172A
  • PTPNS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
transcription factor perturbation
0.91
disease perturbation
0.9
virus perturbation
0.88
transcription factor
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.16   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 784   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.16   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 784   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0