Tbio ANKRD28 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Protein Summary

Description

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Uniprot Accession IDs

• O15084
• B4DES5
• Q1WWL4
• Q29RW6
• Q3B857
• Q6ULS0
• Q6ZT57
• PP6-ARS-A

Gene Name

• ANKRD28

Ensembl ID

• ENST00000399451
• ENSP00000382379
• ENSG00000206560
• ENST00000412318
• ENSP00000397341
• ENST00000624145
• ENSP00000485421

Symbol

• KIAA0379
• PITK
• PPP1R65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
kinase perturbation	0.91
histone modification site profile	0.89
transcription factor	0.85
microRNA	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.29   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.29   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0