Tbio HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Protein Summary

Description

Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.

Uniprot Accession IDs

• Q8TB92
• B1AQ42
• B3KNV0
• B7Z1S7
• F8W793
• Q6ZSA9

Gene Name

• HMGCLL1

Ensembl ID

• ENST00000274901
• ENSP00000274901
• ENSG00000146151
• ENST00000308161
• ENSP00000309737
• ENST00000370852
• ENSP00000359889
• ENST00000398661
• ENSP00000381654

Symbol

• er-cHL
• bA418P12.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
tissue sample	0.69
cellular component	0.61
histone modification site profile	0.52
cell line	0.51

Protein Classes

PANTHER Classes

Protein / Transferase / 3-hydroxymethyl-3-methylglutaryl-coa Lyase, Cytoplasmic

Protein / Lyase / 3-hydroxymethyl-3-methylglutaryl-coa Lyase, Cytoplasmic

DTO Classes

Protein / Enzyme / Transferase / 3-hydroxymethyl-3-methylglutaryl-coa Lyase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0