Tbio HM13 Minor histocompatibility antigen H13

Protein Summary

Description

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TCT9
• B2RAY5
• E1P5L3
• Q15K36
• Q540H8
• Q5JWP2
• Q5JWP3
• Q5JWP4
• Q5JWP5
• Q7Z4F2
• Q86Y35
• Q95H87
• Q9H110
• Q9H111

Gene Name

• HM13

Ensembl ID

• ENST00000335574
• ENSP00000335294
• ENSG00000101294
• ENST00000340852
• ENSP00000343032
• ENST00000398174
• ENSP00000381237

Symbol

• H13
• IMP1
• PSL3
• SPP
• H13
• SPP
• IMP1
• PSL3
• IMPAS
• SPPL1
• PSENL3
• IMPAS-1
• MSTP086

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.95
cellular component	0.84
kinase perturbation	0.84
interacting protein	0.75

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Minor Histocompatibility Antigen H13

Protein / ... / Aspartic Protease / Minor Histocompatibility Antigen H13

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Minor Histocompatibility Antigen H13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0