Protein Summary
Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
- ENST00000336429
- ENSP00000337212
- ENSG00000166396
- ENST00000398019
- ENSP00000381101
- ENST00000540675
- ENSP00000444572
- ENST00000546027
- ENSP00000444861
- PPKN
- TP55
- MEGSIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.8 | ||
transcription factor | 0.57 | ||
biological process | 0.54 | ||
cell line | 0.5 | ||
microRNA | 0.48 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.2 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 172 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.2 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 172 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0