You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SERPINB8
Serpin B8

Protein Summary
Description
Has an important role in epithelial desmosome-mediated cell-cell adhesion. The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353706
  • ENSP00000331368
  • ENSG00000166401
  • ENST00000397985
  • ENSP00000381072
  • ENST00000397988
  • ENSP00000381075
  • ENST00000542677
  • ENSP00000438328

Symbol
  • PI8
  • PI8
  • CAP2
  • PI-8
  • PSS5
  • C18orf53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
tissue sample
0.68
cell type or tissue
0.62
interacting protein
0.62
microRNA
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0