NOXO1
NADPH oxidase organizer 1
Protein Summary
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
- ENST00000354249
- ENSP00000346195
- ENSG00000196408
- ENST00000356120
- ENSP00000348435
- ENST00000397280
- ENSP00000380450
- ENST00000566005
- ENSP00000456800
- P41NOX
- SH3PXD5
- SNX28
- P41NOX
- P41NOXA
- P41NOXB
- P41NOXC
- SH3PXD5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.74 | ||
molecular function | 0.49 | ||
cell line | 0.48 | ||
metabolite | 0.45 | ||
biological term | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.15 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 192 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.15 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 192 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0