Tdark PLA2G4F Cytosolic phospholipase A2 zeta

Protein Summary

Description

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).

Uniprot Accession IDs

• Q68DD2
• Q6ZMC8
• cPLA2-zeta

Gene Name

• PLA2G4F

Ensembl ID

• ENST00000397272
• ENSP00000380442
• ENSG00000168907

Symbol

• PLA2G4FZ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
metabolite	0.78
biological process	0.77
cell line	0.67
cellular component	0.61

Protein Classes

PANTHER Classes

Protein / Hydrolase / Lipase / Phospholipase / Cytosolic Phospholipase A2 Zeta

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Cytosolic Phospholipase A2 Zeta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.5   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.5   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0