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Tbio
GPR135
G-protein coupled receptor 135

Protein Summary
Description
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395116
  • ENSP00000378548
  • ENSG00000181619
  • ENST00000481661
  • ENSP00000432696

Symbol
  • HUMNPIIY20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
cell type or tissue
0.58
tissue sample
0.56
cell line
0.53
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.86   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.86   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0