You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
VKORC1
Vitamin K epoxide reductase complex subunit 1

Protein Summary
Description
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative spl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319788
  • ENSP00000326135
  • ENSG00000167397
  • ENST00000354895
  • ENSP00000346969
  • ENST00000394975
  • ENSP00000378426

Symbol
  • VKOR
  • VKOR
  • MST134
  • MST576
  • VKCFD2
  • EDTP308
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
biological term
0.98
transcription factor perturbation
0.94
transcription factor binding site profile
0.84
virus perturbation
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 833.34   (req: < 5)
Gene RIFs: 337   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 833.34   (req: >= 5)
Gene RIFs: 337   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5