Tbio GTF2F1 General transcription factor IIF subunit 1

Protein Summary

Description

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

Uniprot Accession IDs

• P35269
• B2RCS0
• Q9BWN0

Gene Name

• GTF2F1

Ensembl ID

• ENST00000394456
• ENSP00000377969
• ENSG00000125651

Symbol

• RAP74
• BTF4
• RAP74
• TF2F1
• TFIIF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
disease perturbation	0.95
histone modification site profile	0.92
hub protein	0.85
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / General Transcription Factor Iif Subunit 1

Protein / Nucleic Acid Binding / General Transcription Factor Iif Subunit 1

DTO Classes

Protein / Nucleic Acid Binding / General Transcription Factor Iif Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.92   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.92   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0