Tbio FHL1 Four and a half LIM domains protein 1

Protein Summary

Description

May have an involvement in muscle development or hypertrophy. This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q13642
• B7Z5T4
• B7Z793
• O95212
• Q13230
• Q13645
• Q5JXI7
• Q5M7Y6
• Q6IB30
• Q9NZ40
• Q9UKZ8
• Q9Y630
• FHL-1

Gene Name

• FHL1

Ensembl ID

• ENST00000345434
• ENSP00000071281
• ENSG00000022267
• ENST00000370683
• ENSP00000359717
• ENST00000370690
• ENSP00000359724
• ENST00000394153
• ENSP00000377709
• ENST00000394155
• ENSP00000377710
• ENST00000535737
• ENSP00000444815
• ENST00000539015
• ENSP00000437673
• ENST00000543669
• ENSP00000443333
• ENST00000618438
• ENSP00000477609
• ENST00000628568
• ENSP00000486782
• ENST00000629039
• ENSP00000486439
• ENST00000630084
• ENSP00000485897

Symbol

• SLIM1
• KYOT
• SLIM
• FCMSU
• FHL-1
• FHL1A
• FHL1B
• FLH1A
• SLIM1
• XMPMA
• RBMX1A
• RBMX1B
• SLIM-1
• SLIMMER

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.99
transcription factor perturbation	0.97
PubMedID	0.92
kinase perturbation	0.91
hub protein	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.99   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 439   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.99   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 439   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0