You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZDHHC16
Palmitoyltransferase ZDHHC16

Protein Summary
Description
Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345745
  • ENSP00000304487
  • ENSG00000171307
  • ENST00000352634
  • ENSP00000345383
  • ENST00000353979
  • ENSP00000323360
  • ENST00000370842
  • ENSP00000359879
  • ENST00000370854
  • ENSP00000359891
  • ENST00000393760
  • ENSP00000377357

Symbol
  • APH2
  • APH2
  • DHHC-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.89
disease perturbation
0.68
virus perturbation
0.68
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0