Tdark RGL3 Ral guanine nucleotide dissociation stimulator-like 3

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Uniprot Accession IDs

• Q3MIN7
• B5ME84
• B7ZL22
• Q0P6G0
• RalGDS-like 3

Gene Name

• RGL3

Ensembl ID

• ENST00000393423
• ENSP00000377075
• ENSG00000205517

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
gene perturbation	0.84
transcription factor	0.59
tissue sample	0.53
cell type or tissue	0.5

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ral Guanine Nucleotide Dissociation Stimulator-like 3

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ral Guanine Nucleotide Dissociation Stimulator-like 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0