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Tbio
PRIMA1
Proline-rich membrane anchor 1

Protein Summary
Description
Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity). The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316227
  • ENSP00000320948
  • ENSG00000175785
  • ENST00000393140
  • ENSP00000376848
  • ENST00000393143
  • ENSP00000376851
  • ENST00000477603
  • ENSP00000434370
  • ENST00000611347
  • ENSP00000479082
  • ENSG00000274089
  • ENST00000617019
  • ENSP00000479855
  • ENST00000627063
  • ENSP00000486875
  • ENST00000629961
  • ENSP00000486953

Symbol
  • PRIMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
cell type or tissue
0.56
PubMedID
0.56
tissue
0.51
transcription factor binding site profile
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.57   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.57   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0