Tbio VTI1A Vesicle transport through interaction with t-SNAREs homolog 1A

Protein Summary

Description

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q96AJ9
• A2A307
• B4E137
• Q5W0D7

Gene Name

• VTI1A

Ensembl ID

• ENST00000393077
• ENSP00000376792
• ENSG00000151532
• ENST00000432306
• ENSP00000395017

Symbol

• MMDS3
• MVti1
• VTI1RP2
• Vti1-rp2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
histone modification site profile	0.91
cellular component	0.85
cell type or tissue	0.77
interacting protein	0.73

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Vesicle Transport Through Interaction With T-snares Homolog 1a

DTO Classes

Protein / Transporter / Snare Protein / Vesicle Transport Through Interaction With T-snares Homolog 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.22   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.22   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0