Tbio ABCA5 ATP-binding cassette sub-family A member 5

Protein Summary

Description

May play a role in the processing of autolysosomes. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WWZ7
• Q8IVJ2
• Q96LJ1
• Q96MS4
• Q96PZ9
• Q9NY14

Gene Name

• ABCA5

Ensembl ID

• ENST00000392676
• ENSP00000376443
• ENSG00000154265
• ENST00000588877
• ENSP00000467882

Symbol

• KIAA1888
• HTC3
• ABC13
• EST90625

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
virus perturbation	0.97
histone modification site profile	0.85
protein domain	0.85
cell type or tissue	0.82

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family A Member 5

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abca Subfamily / Atp-binding Cassette Sub-family A Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.8   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.8   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0