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Tbio
PTOV1
Prostate tumor-overexpressed gene 1 protein

Protein Summary
Description
May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391842
  • ENSP00000375717
  • ENSG00000104960
  • ENST00000599732
  • ENSP00000469128
  • ENST00000601675
  • ENSP00000472816

Symbol
  • ACID2
  • ACID2
  • PTOV-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
disease perturbation
0.83
cell type or tissue
0.73
transcription factor binding site profile
0.66
transcription factor
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.82   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.82   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0