Tdark TRMT44 Probable tRNA (uracil-O(2)-)-methyltransferase

Protein Summary

Description

Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q8IYL2
• Q8NA95

Gene Name

• TRMT44

Ensembl ID

• ENST00000389737
• ENSP00000374387
• ENSG00000155275
• ENST00000513449
• ENSP00000424643

Symbol

• C4orf23
• METTL19
• TRM44
• C4orf23
• METTL19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor binding site profile	0.83
cell type or tissue	0.8
histone modification site profile	0.68
transcription factor	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 31   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0