Tbio CADPS Calcium-dependent secretion activator 1

Protein Summary

Description

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• Q9ULU8
• A6NF60
• Q13339
• Q6GQQ6
• Q8N2Z5
• Q8N3M7
• Q8NFR0
• Q96BC2

Gene Name

• CADPS

Ensembl ID

• ENST00000283269
• ENSP00000283269
• ENSG00000163618
• ENST00000357948
• ENSP00000350632
• ENST00000383710
• ENSP00000373215
• ENST00000490353
• ENSP00000418736

Symbol

• CAPS
• CAPS1
• KIAA1121
• CAPS
• CAPS1
• CADPS1
• UNC-31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
cell type or tissue	0.8
transcription factor perturbation	0.8
protein domain	0.73
PubMedID	0.7

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Calcium-dependent Secretion Activator 1

DTO Classes

Protein / Calcium-binding Protein / Calcium-dependent Secretion Activator 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0