NSD2
Histone-lysine N-methyltransferase NSD2
Protein Summary
Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]
- ENST00000312087
- ENSP00000308780
- ENSG00000109685
- ENST00000353275
- ENSP00000329167
- ENST00000382888
- ENSP00000372344
- ENST00000382891
- ENSP00000372347
- ENST00000382892
- ENSP00000372348
- ENST00000382895
- ENSP00000372351
- ENST00000398261
- ENSP00000381311
- ENST00000420906
- ENSP00000399251
- ENST00000436793
- ENSP00000416725
- ENST00000503128
- ENSP00000425761
- ENST00000508803
- ENSP00000423972
- ENST00000512700
- ENSP00000427516
- ENST00000514045
- ENSP00000421681
- KIAA1090
- MMSET
- TRX5
- WHSC1
- WHS
- TRX5
- KMT3F
- KMT3G
- MMSET
- WHSC1
- REIIBP
Most Knowledge About | Knowledge Value
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biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 251.45 (req: < 5)
Gene RIFs: 109 (req: <= 3)
Antibodies: 176 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 251.45 (req: >= 5)
Gene RIFs: 109 (req: > 3)
Antibodies: 176 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 38
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0