Tbio AFAP1 Actin filament-associated protein 1

Protein Summary

Description

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• Q8N556
• A8K442
• B4DMU2
• E9PDT7
• Q59EY5
• Q9HBY1

Gene Name

• AFAP1

Ensembl ID

• ENST00000358461
• ENSP00000351245
• ENSG00000196526
• ENST00000360265
• ENSP00000353402
• ENST00000382543
• ENSP00000371983
• ENST00000420658
• ENSP00000410689

Symbol

• AFAP
• AFAP
• AFAP110
• AFAP-110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
ligand (protein) perturbation	0.83
small molecule perturbation	0.76
hub protein	0.75
cell type or tissue	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.39   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 425   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.39   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 425   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0