You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KDM4C
Lysine-specific demethylase 4C

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381306
  • ENSP00000370707
  • ENSG00000107077
  • ENST00000381309
  • ENSP00000370710
  • ENST00000536108
  • ENSP00000440656
  • ENST00000543771
  • ENSP00000445427

Symbol
  • GASC1
  • JHDM3C
  • JMJD2C
  • KIAA0780
  • GASC1
  • JHDM3C
  • JMJD2C
  • TDRD14C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
transcription factor binding site profile
0.91
transcription factor
0.83
disease perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.01   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.01   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 358
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0